Adding product to your cart
What is it?
Cancer is one of the leading causes of death both in the United States and worldwide. Recently, the field of immunotherapy has proven incredibly promising as a novel treatment method. Immunotherapy works by retargeting the immune system, which normally attacks invading pathogens such as bacteria or virally infected cells, to kill cancer cells instead. The power of immunotherapy lies in two main abilities: the fact that the immune system is capable of eradicating both a tumor and its distant metastases, which surgery and radiation are not able to do, and that immunological memory may prevent relapse of the cancer cells if they begin growing again. One type of immune cell that is known for its cancer cell-killing ability is the natural killer (NK) cell, but engineering these cells is difficult and as such there have not been many successful clinical trials using these cells against solid tumors yet.
I would like to engineer NK cells into tuneable cell therapeutics that can be combined with tumor-targeting antibodies to initiate an antitumor immune response in patients regardless of their genetic makeup or the profile of their tumor. I will do this by combining novel chimeric antigen receptors (CARs) with other activating receptors, as well as expressing activating molecules on feeder cells that can be used to cause the NK cells to proliferate and differentiate into even stronger killers. By designing a truly universal off-the-shelf cell therapeutic, I will be able to drastically decrease the cost of cell-based immunotherapy compared to the current CAR T cell production methods – this can cost almost half of a million dollars per patient and needs to be made on an individual basis, which also causes variability in the final product. By modulating both the feeder cells and the NK cells, I hope to create stronger immune synapses between the NK cells and the tumor cells they will target in patients and ideally improve clinical outcomes for patients with cancer.
What can it be used for?
The genes listed here can be expressed on NK cells, feeder cells, or tumor cells to study individual NK cell signaling pathways, strengths of activation of different receptor-ligand interactions, and whether certain NK cells are more or less resistant to inhibitory cues from cancer cells. These can all be combined in various combinations or used individually to assess synergistic effects as well. The CARs can be used to make NK cells that target surface molecules on B cells or any other cells, as long as an antibody or other targeting molecule can be designed against it.
Where can I find more information?
https://en.wikipedia.org/wiki/Cancer_immunotherapy
https://en.wikipedia.org/wiki/Chimeric_antigen_receptor_T_cell
https://en.wikipedia.org/wiki/Natural_killer_cell
https://en.wikipedia.org/wiki/Antibody
Designed By: Nina Horowitz, Stanford University
Image Source
Genes
Bionet
The bionet enables open peer-peer exchange of functional biomaterials and associated data. This product may also be available from bionet nodes that are more convenient to you. Here are other bionet nodes who may be willing to provide you this specific product.
MTA
Unilateral OpenMTA
NOTICE OF CONDITIONS
Upon acceptance and use of this Material, the Recipient agrees to the following conditions:
- Use: The Recipient shall use, store, and dispose of the Material and any Modifications in accordance with good laboratory practice and shall ensure compliance with all applicable laws, rules, and regulations, including laws, rules, and regulations governing export control and safety.
- Attribution: The Recipient has no obligation to acknowledge the Provider
- Distribution: The Recipient may distribute the Material and substances created by the Recipient through use of the Material, including Progeny, Unmodified Derivatives, and Modifications, without requesting consent from the Provider. The Provider DISCLAIMS ALL RIGHTS of notification regarding any distribution of the Material by the Recipient to third parties.
- Fees: The Material is provided at no cost, or with an optional transmittal fee solely to reimburse the Provider for its preparation and distribution costs.
- Intellectual Property: The Provider disclaims all intellectual and other property rights to the supplied Materials. Should Recipient use the Materials to develop novel products or processes, the Provider will not at any time claim downstream rights to these products or processes, or to any subsequent innovations that flow from them.
- No Implied License: Except for the rights expressly granted herein, the Recipient agrees that no other rights or licenses, whether express or implied, are granted to the Recipient under any patent, patent application, or other proprietary right of the Provider. As between the parties, each retains all right, title, and interest in works and inventions made by its personnel, and nothing herein shall be construed to transfer ownership of any invention, patent, patent application, or other proprietary right.
- Liability: Except to the extent prohibited by law, the Recipient assumes all liability for damages that may arise from the use, storage or disposal of the Material. The Provider will not be liable to the Recipient for any loss, claim or demand made by the Recipient, or made against the Recipient by any other party, due to or arising from the use of the Material by the Recipient, except to the extent permitted by law when caused by the gross negligence or willful misconduct of the Provider.
- No Warranties: Any Material delivered pursuant to the Agreement is understood to be experimental in nature and may have hazardous properties. THE PROVIDER MAKES NO REPRESENTATIONS AND EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESSED OR IMPLIED. THERE ARE NO EXPRESS OR IMPLIED WARRANTIES OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR THAT THE USE OF THE MATERIAL WILL NOT INFRINGE ANY PATENT, COPYRIGHT, TRADEMARK, OR OTHER PROPRIETARY RIGHTS.
DEFINITIONS:
- Material: Original Material, Progeny, and Unmodified Derivatives. The Material shall not include: (a) Modifications, or (b) other substances created by the Recipient through the use of the Material, which are not Modifications, Progeny, or Unmodified Derivatives.
- Progeny: Unmodified descendant from the Material, such as virus from virus, cell from cell, or organism from organism.
- Unmodified Derivatives: Substances created by the Recipient which constitute an unmodified functional subunit or product expressed by the Original Material. Some examples include: subclones of unmodified cell lines, purified or fractionated subsets of the Original Material, proteins expressed by DNA/RNA supplied by Provider, or monoclonal antibodies secreted by a hybridoma cell line.
- Modifications: Substances created by the Recipient which contain/incorporate the Material.
Use left/right arrows to navigate the slideshow or swipe left/right if using a mobile device