Boolean Integrase Logic (BIL) Gates

Boolean Integrase Logic (BIL) Gates

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What is it?

We developed a three-terminal device architecture, termed the transcriptor, that uses bacteriophage serine integrases to control the flow of RNA polymerase along DNA. Integrase-mediated inversion or deletion of DNA encoding transcription terminators or a promoter modulates transcription rates. We realized permanent amplifying AND, NAND, OR, XOR, NOR, and XNOR gates actuated across common control signal ranges and sequential logic supporting autonomous cell-cell communication of DNA encoding distinct logic-gate states. The single-layer digital logic architecture developed here enables engineering of amplifying logic gates to control transcription rates within and across diverse organisms. 


What can it be used for?

Two-input logic and/or data storage in a simple DNA register.  Native or heterologous transcription sources can flip the gates.


Where can I find more information?

Amplifying Genetic Logic Gates, Jerome Bonnet Peter Yin Monica E. Ortiz Pakpoom Subsoontorn Drew Endy


All genes are present on the plate in E. coli glycerol stocks. If you've already received the plate, check out the plate layout.



Gene Name
AND-gate-V2.0 AND-gate-V2.0
OR gate OR gate
NOR gate-V2.0 NOR gate-V2.0
XOR gate-V2.0 XOR gate-V2.0
Dual-recombinase-controller Dual-recombinase-controller


The bionet enables open peer-peer exchange of functional biomaterials and associated data. This product may also be available from bionet nodes that are more convenient to you. Here are other bionet nodes who may be willing to provide you this specific product.

Name Contact
Jordan Gonzalez jgonzalez {at} thecitizensciencelab {dot} org